assuming we're talking about the cb750, yes there are 2 coils: one for cylinders 1 and 4 and one for 2 and 3.
One coil is fired by a blue wire, and the other is fired by a yellow wire. The coils share a common connection (black wire, if memory serves).
One test is to let the bike cool down all the way (overnight) and try again the next morning. If you have a Battery Tender or similar device, connect it to your battery in case you have to do lots of cranking on the starter. If it starts and runs, then it's possible it's temperature related. If it doesn't start the next morning, then something else has gone sour. I'd recommend getting the manual from this site, and starting at one end of the ignition system and checking everything from the pulsers or points (depends on the year of your bike) through all the electrics (the DOHC pulsers have igniter systems, the SOHC points act directly with the coils), all the way down to the spark plugs.
When it's running, it's running strong with no lack of power or missing in the engine?
Did you change something recently? New plugs, carb adjustments, coils, battery?
Is the timing properly set? The procedure is also in the manual. Pretty easy for DOHC, a little more involved for SOHC.
That should get you started (no pun intended). Let us know what you find, and if we can help further. Good luck.
Luke M
Used to have a 1979 CB750L, sold it as a parts bike, now riding a slightly modified 1984 VT700C. Network/Field Engineer. Central OH, USA, Earth, Sol System, Milky Way Galaxy, Universe.