I have an 81 750F. The stock sprockets were 46/18 (2.56 ratio). When I went to replace the sprockets and chain last year I ordered the same (46/18 with 108 link chain). Sunstar didn't have a 46 and mistakenly sent a 42. I talked to my Honda Doc and he advised me to go down a tooth in the front to stay as close a possible to the original ratio. So I changed to a 42/17 (2.47 ratio). In doing so, I had to remove one link in the chain (which, in reality, is 2 links as previously pointed out). If you are not changing your front sprocket you may not need to take out that link . If you're getting a fixed link chain, test it before taking out a link. If your adjusters are too far back take out a link. I was trying to keep my adjusters as tight as possible knowing that the chain will stretch and teh sprockets would wear down in time.
By the way, I am running about 500 rpm lower at highway speeds than previously.
Chris
'81 CB750F