By "the weekend" do you mean that you have an entire weekend to dedicate to it, if so then yes there are a few things you can do in that time. If you are like me and have a kid to play with, dinner to make, a lawn to mow, etc. then no a weekend won't do it
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There is an absolutely fantastic carb cleaning manual that you can download for free, and if you're going to clean them I recommend just getting the full kit from Randakk, it'll make your life a lot easier. That said, I wouldn't do a full carb cleaning just yet. Start with just syncing them. From the sounds of it you aren't having fuel delivery issues, so cleaning the carbs won't help with the knock.
Syncing the carbs will take you an hour or two if you're really slow.
To sync them you'll need a carb sync tool (e.g:
http://www.carbtune.com/ - you need the 4 column one), and a tool to make turning the screws easy (e.g.
http://www.carbtune.co.uk/carbtool.html). You will also need either a long fuel hose so you can set your gas tank up high and run the fuel hose to the carbs or it could just be a small vessel you make (heck an old 2L plastic coke bottle would work if you could get the hose to seal well).
There are plans on the internet on how to make your own carb sync tool if you have lots of time and want to save money, and you can get away with not having the specialized tool to for turning the screws with locknuts, it just takes longer (I am very happy I bought mine).
You can also do your own search to find some cheaper models than the carbtune. I ended up getting that one so that's why I linked to it.
1981 CB750K with 900 cams
90K KM's, rebuilt head, rebuilt carbs, upgraded valve stem seals
My wife's recipe website that I'm trying to help promote:
Strawberries for supper. Yes, I am a lucky man.
My
cb750 video site