Sorry, I should go more into specifics. I had this same issue. If it's a sticky float, debris is keeping the float from moving freely. Whacking the bowl of the problem carb with a non-metal object (to prevent sparks) can help dislodge it, and cleaning the carbs thoroughly is a more permanent solution. Debris can also cause the needle valve to not seat correctly, and whacking the bowl can sometimes help that too. I've heard that varnished gas and filth can build up on the needle valve seats, so what I did was give the seats a quick polish with a q-tip and toothepaste (you can use fine abrasive too).
If the drain screw isn't seating correctly, take the bowl off and clear out the debris with compressed air. I'd be gentle with physical cleaning tools because that threading is aluminum and probably pretty delicate.
What ended up being my problem were tiny splits in the brass sections of the bowl's drain tubes, which really do require magnifying glasses and good light to see. You can also test for them by filling the removed bowl with gas, connecting a rubber drain tube to the drain plug on the bottom, covering the opening of the brass tube with your finger, and blowing into the tube (holding it above the gas surface, of course). If there are bubbles, you have a leak. Testing by seeing if water leaks out of the bowl, which is what I did because it was less messy and available right out of the tap, won't work because it won't seep through the cracks like gas can, so don't try it. If you find cracks, you can braze or JB weld them shut. I'd recommend brazing because I don't think JB weld is gas-proof in the long run.
You can also test to see if your floats are leaking by a simple test of submerging them in gasoline overnight and seeing if they take on gas. Pretty straightforward.
Good luck!
1979 CB750K