Have you tried to spit test to see if any pipes are running cooler than others? Good dab of spit on a finger and very quickly touch the header. Don't touch hard as you'll push the spit away and it can't protect the finger. If it sizzles, the pipe is hot. If it does not, then it is cold. You could do a laser temp gun, but I am a cheap ass.
Also, I would pull the plugs out as soon as the issue starts. Doing it this soon might reveal which cylinders are not playing nice.
What air filter are you running?
Have you verified your flaps in the carbs are opening and closing properly? The issue seems to start occurring as the bike warms up. Maybe there is some choking happening and it is causing the plugs to foul.
The ride IS the adventure. The destination is just to get gas!